Quantifying variability in individual specific trajectories between NACC

 
   Lead Investigator:    Jennifer Koontz
   Institution      :    UC Irvine
   E-Mail           :    jkoontz@occ.cccd.edu
   Proposal ID      :    107



   Proposal Description:
   This proposal will examine differences in the rates of cognitive decline in  neuropsychological testing between the ADC and ADRC???s as a first step in  determining whether or not learning, or retest, effects contribute to increased  variability in individual level test trajectories across centers. The proposed  study will address suggested topic #424: Center Differences in Rate of Decline  and will use this information to examine retest effects.  In addition, the  study will consider additional confounding factors that may be contributing to  the masking of cognitive decline through higher performance on  neuropsychological tests in the UDS, including education level, neuropathology  data, and APOE status.